Immune Privilege Revisited: The Roles of Neuronal MHC Class I Molecules in Brain Development and Plasticity
نویسنده
چکیده
Ever since its initial discovery in 1948 by George Snell, major histocompatibility (MHC) complex became the focus of intense research that, due to its diverse roles, gradually extended far beyond transplantation biology. MHC class I molecules are found on virtually all nucleated cells of jawed vertebrates and are the most polymorphic molecules described to date (Cresswell et al. 2005, Solheim 1999). Their polymorphism is so high that, with the exception of identical twins, two individuals with the exact same set of MHC molecules (both class I and II) do not exist.
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